Nelson, David L. creator Cox, Michael M. autor text nyu 2008 5a edición monographic eng 1 v. (en varias paginaciones) : ilustraciones, gráficas, diagramas, tablas, fotos In the Fifth Edition, authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles through a variety of new learning tools--from new in-text worked examples and data analysis problems to the breakthrough eBook, which seamlessly integrates the complete text and its media components. The Foundations of Biochemistry -- Cellular Foundations -- Chemical Foundations -- Physical Foundations -- Genetic Foundations -- Evolutionary Foundations -- Molecular Weight, Molecular Mass, and Their Correct Units -- Louis Pasteur and Optical Activity: In Vino, Veritas -- Entropy: The Advantages of Being Disorganized -- Now introduces the concepts of proteomes and proteomics -- Updated section on how a new species evolves -- Increased emphasis on the interdependence of life forms in global cycles of energy -- Structure and Catalysis -- Water -- Weak Interactions in Aqueous Systems -- Ionization of Water, Weak Acids, and Weak Bases -- Buffering against pH Changes in Biological Systems -- Water as a Reactant -- The Fitness of the Aqueous Environment for Living Organisms -- Amino Acids, Peptides, and Proteins -- Amino Acids -- Peptides and Proteins -- Working with Proteins -- The Structure of Proteins: Primary Structure -- Methods: Absorption of Light by Molecules: The Lambert-Beer Law -- Methods: Investigating Proteins with Mass Spectrometry -- Medicine: Consensus Sequences and Sequence Logos -- The Three-Dimensional Structure of Proteins -- Overview of Protein Structure -- Protein Secondary Structure -- Protein Tertiary and Quaternary Structures -- Protein Denaturation and Folding -- Methods: Knowing the Right Hand from the Left -- Permanent Waving Is Biochemical Engineering -- Medicine: Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables -- The Protein Data Bank -- Methods: Methods for Determining the Three-Dimensional Structure of a Protein -- Medicine: Death by Misfolding: The Prion Diseases -- New section, Defects in protein folding may be the molecular basis for a wide range of human genetic disorders, discusses a variety of amyloid diseases -- New section on circular dichroism -- Protein Function -- Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins -- Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins -- Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors -- Medicine: Carbon Monoxide: A Stealthy Killer -- Enzymes -- An Introduction to Enzymes -- How Enzymes Work -- Enzyme Kinetics as an Approach to Understanding Mechanism -- Examples of Enzymatic Reactions -- Regulatory Enzymes -- Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot -- Kinetic Tests for Determining Inhibition Mechanisms -- Evidence for Enzyme-Transition State Complementarity -- More explanatory text added to the mechanisms for the enolase and lysozyme reactions -- New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples -- Carbohydrates and Glycobiology -- Monosaccharides and Disaccharides -- Polysaccharides -- Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids -- Carbohydrates as Informational Molecules: The Sugar Code -- Working with Carbohydrates -- Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes -- New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes -- New section on sugar analogs as drugs that target viral neuraminidase -- Introduction to the new field of glycomics, including methods for determining oligosaccharide structure using MALDI-MS -- Nucleotides and Nucleic Acids -- Some Basics -- Nucleic Acid Structure -- Nucleic Acid Chemistry -- Other Functions of Nucleotides -- DNA-Based Information Technologies -- DNA Cloning: The Basics -- From Genes to Genomes -- From Genomes to Proteomes -- Genome Alterations and New Products of Biotechnology -- Medicine: A Potent Weapon in Forensic Medicine -- Medicine: The Human Genome and Human Gene Therapy -- New material on the green fluorescent protein -- Thorough updating of genomics section -- Lipids -- Storage Lipids -- Structural Lipids in Membranes -- Lipids as Signals, Cofactors, and Pigments -- Working with Lipids -- Sperm Whales: Fatheads of the Deep -- Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases -- New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease -- New section on lipidomics -- New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods -- Biological Membranes and Transport -- The Composition and Architecture of Membranes -- Membrane Dynamics -- Solute Transport across Membranes -- Methods: Atomic Force Microscopy to Visualize Membrane Proteins -- Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes -- Medicine: A Defective Ion Channel in Cystic Fibrosis -- Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry -- Expanded and updated section on lipid rafts and caveolae includes new material on membrane curvature and the proteins that influence it, and introduces amphitropic proteins and annular lipids -- New information on the structural basis for voltage gating in a K+ channel specialized David L. Nelson y Michael M. Cox Incluye bibliografías Bioquímica Biochemistry QH345 .N45 2008 574.192 N45 2008 978-0-7167-7108-1 0-7167-7108-X 177373 mxchpua 220117 20250707102227.0 dia_6453