06877nam a2200397 a 4500001000900000003000500009005001700014007000300031008004100034010001100075020002200086020001800108040002300126041002300149050002100172082002700193100002800220245007700248250001700325300008900342336002700431337002700458338002800485504002800513505518600541520039605727650003106123650003006154700003406184901002106218902000606239905006306245942001506308999001906323952013706342dia_6453CHAP20250707102227.0ta220117s2008 nyuado fr 001 0 eng d a177373 a978-0-7167-7108-1 a0-7167-7108-X cCHAPamxchpuaerda aengbengfengheng1 aQH345b.N45 2008 220a574.192 bN45 20081 aNelson, David L.98077310aLehninger Principles of biochemistry /cDavid L. Nelson y Michael M. Cox a5a edición a1 v. (en varias paginaciones) :bilustraciones, gráficas, diagramas, tablas, fotos 2rdacontentatextobtxt 2rdamediaasin mediobn 2rdacarrieravolumenbnc aIncluye bibliografías0 aThe Foundations of Biochemistry -- Cellular Foundations -- Chemical Foundations -- Physical Foundations -- Genetic Foundations -- Evolutionary Foundations -- Molecular Weight, Molecular Mass, and Their Correct Units -- Louis Pasteur and Optical Activity: In Vino, Veritas -- Entropy: The Advantages of Being Disorganized -- Now introduces the concepts of proteomes and proteomics -- Updated section on how a new species evolves -- Increased emphasis on the interdependence of life forms in global cycles of energy -- Structure and Catalysis -- Water -- Weak Interactions in Aqueous Systems -- Ionization of Water, Weak Acids, and Weak Bases -- Buffering against pH Changes in Biological Systems -- Water as a Reactant -- The Fitness of the Aqueous Environment for Living Organisms -- Amino Acids, Peptides, and Proteins -- Amino Acids -- Peptides and Proteins -- Working with Proteins -- The Structure of Proteins: Primary Structure -- Methods: Absorption of Light by Molecules: The Lambert-Beer Law -- Methods: Investigating Proteins with Mass Spectrometry -- Medicine: Consensus Sequences and Sequence Logos -- The Three-Dimensional Structure of Proteins -- Overview of Protein Structure -- Protein Secondary Structure -- Protein Tertiary and Quaternary Structures -- Protein Denaturation and Folding -- Methods: Knowing the Right Hand from the Left -- Permanent Waving Is Biochemical Engineering -- Medicine: Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables -- The Protein Data Bank -- Methods: Methods for Determining the Three-Dimensional Structure of a Protein -- Medicine: Death by Misfolding: The Prion Diseases -- New section, Defects in protein folding may be the molecular basis for a wide range of human genetic disorders, discusses a variety of amyloid diseases -- New section on circular dichroism -- Protein Function -- Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins -- Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins -- Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors -- Medicine: Carbon Monoxide: A Stealthy Killer -- Enzymes -- An Introduction to Enzymes -- How Enzymes Work -- Enzyme Kinetics as an Approach to Understanding Mechanism -- Examples of Enzymatic Reactions -- Regulatory Enzymes -- Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot -- Kinetic Tests for Determining Inhibition Mechanisms -- Evidence for Enzyme-Transition State Complementarity -- More explanatory text added to the mechanisms for the enolase and lysozyme reactions -- New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples -- Carbohydrates and Glycobiology -- Monosaccharides and Disaccharides -- Polysaccharides -- Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids -- Carbohydrates as Informational Molecules: The Sugar Code -- Working with Carbohydrates -- Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes -- New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes -- New section on sugar analogs as drugs that target viral neuraminidase -- Introduction to the new field of glycomics, including methods for determining oligosaccharide structure using MALDI-MS -- Nucleotides and Nucleic Acids -- Some Basics -- Nucleic Acid Structure -- Nucleic Acid Chemistry -- Other Functions of Nucleotides -- DNA-Based Information Technologies -- DNA Cloning: The Basics -- From Genes to Genomes -- From Genomes to Proteomes -- Genome Alterations and New Products of Biotechnology -- Medicine: A Potent Weapon in Forensic Medicine -- Medicine: The Human Genome and Human Gene Therapy -- New material on the green fluorescent protein -- Thorough updating of genomics section -- Lipids -- Storage Lipids -- Structural Lipids in Membranes -- Lipids as Signals, Cofactors, and Pigments -- Working with Lipids -- Sperm Whales: Fatheads of the Deep -- Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases -- New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease -- New section on lipidomics -- New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods -- Biological Membranes and Transport -- The Composition and Architecture of Membranes -- Membrane Dynamics -- Solute Transport across Membranes -- Methods: Atomic Force Microscopy to Visualize Membrane Proteins -- Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes -- Medicine: A Defective Ion Channel in Cystic Fibrosis -- Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry -- Expanded and updated section on lipid rafts and caveolae includes new material on membrane curvature and the proteins that influence it, and introduces amphitropic proteins and annular lipids -- New information on the structural basis for voltage gating in a K+ channel 2 aIn the Fifth Edition, authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles through a variety of new learning tools--from new in-text worked examples and data analysis problems to the breakthrough eBook, which seamlessly integrates the complete text and its media components.13aBioquímica 9128492atg13aBiochemistry91504482atg1 aCox, Michael M.928752eautor a574.192 N45 2008 aA a5232272008 -usaimn8222223322eng16 cLIBRO2ddc c177373d177373 00102ddc4051708GRALaIA_bIA_eCompra i238545l1o574.192 N45 2008p1102000915r2023-03-22 00:00:00s2023-03-22tEj. 1yLIBRO