000			06724nam a2200385 a 4500
001			dia_6453
003			CHAP
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007			ta
008			220117s2008 nyuado fr 001 0 eng d
010			_a177373
020			_a978-0-7167-7108-1
020			_a0-7167-7108-X
040			_cCHAP _amxchpua _erda
041			_aeng _beng _feng _heng
050	1		_aQH345 _b.N45 2008
082			_220 _a574.192 _bN45 2008
100	1		_aNelson, David L. _980773
245	1	0	_aLehninger Principles of biochemistry / _cDavid L. Nelson y Michael M. Cox
250			_a5a edición
300			_a1 v. (en varias paginaciones) : _bilustraciones, gráficas, diagramas, tablas, fotos
336			_2rdacontent _atexto _btxt
337			_2rdamedia _asin medio _bn
338			_2rdacarrier _avolumen _bnc
504			_aIncluye bibliografías
505	0		_aThe Foundations of Biochemistry -- Cellular Foundations -- Chemical Foundations -- Physical Foundations -- Genetic Foundations -- Evolutionary Foundations -- Molecular Weight, Molecular Mass, and Their Correct Units -- Louis Pasteur and Optical Activity: In Vino, Veritas -- Entropy: The Advantages of Being Disorganized -- Now introduces the concepts of proteomes and proteomics -- Updated section on how a new species evolves -- Increased emphasis on the interdependence of life forms in global cycles of energy -- Structure and Catalysis -- Water -- Weak Interactions in Aqueous Systems -- Ionization of Water, Weak Acids, and Weak Bases -- Buffering against pH Changes in Biological Systems -- Water as a Reactant -- The Fitness of the Aqueous Environment for Living Organisms -- Amino Acids, Peptides, and Proteins -- Amino Acids -- Peptides and Proteins -- Working with Proteins -- The Structure of Proteins: Primary Structure -- Methods: Absorption of Light by Molecules: The Lambert-Beer Law -- Methods: Investigating Proteins with Mass Spectrometry -- Medicine: Consensus Sequences and Sequence Logos -- The Three-Dimensional Structure of Proteins -- Overview of Protein Structure -- Protein Secondary Structure -- Protein Tertiary and Quaternary Structures -- Protein Denaturation and Folding -- Methods: Knowing the Right Hand from the Left -- Permanent Waving Is Biochemical Engineering -- Medicine: Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables -- The Protein Data Bank -- Methods: Methods for Determining the Three-Dimensional Structure of a Protein -- Medicine: Death by Misfolding: The Prion Diseases -- New section, Defects in protein folding may be the molecular basis for a wide range of human genetic disorders, discusses a variety of amyloid diseases -- New section on circular dichroism -- Protein Function -- Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins -- Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins -- Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors -- Medicine: Carbon Monoxide: A Stealthy Killer -- Enzymes -- An Introduction to Enzymes -- How Enzymes Work -- Enzyme Kinetics as an Approach to Understanding Mechanism -- Examples of Enzymatic Reactions -- Regulatory Enzymes -- Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot -- Kinetic Tests for Determining Inhibition Mechanisms -- Evidence for Enzyme-Transition State Complementarity -- More explanatory text added to the mechanisms for the enolase and lysozyme reactions -- New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples -- Carbohydrates and Glycobiology -- Monosaccharides and Disaccharides -- Polysaccharides -- Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids -- Carbohydrates as Informational Molecules: The Sugar Code -- Working with Carbohydrates -- Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes -- New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes -- New section on sugar analogs as drugs that target viral neuraminidase -- Introduction to the new field of glycomics, including methods for determining oligosaccharide structure using MALDI-MS -- Nucleotides and Nucleic Acids -- Some Basics -- Nucleic Acid Structure -- Nucleic Acid Chemistry -- Other Functions of Nucleotides -- DNA-Based Information Technologies -- DNA Cloning: The Basics -- From Genes to Genomes -- From Genomes to Proteomes -- Genome Alterations and New Products of Biotechnology -- Medicine: A Potent Weapon in Forensic Medicine -- Medicine: The Human Genome and Human Gene Therapy -- New material on the green fluorescent protein -- Thorough updating of genomics section -- Lipids -- Storage Lipids -- Structural Lipids in Membranes -- Lipids as Signals, Cofactors, and Pigments -- Working with Lipids -- Sperm Whales: Fatheads of the Deep -- Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases -- New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease -- New section on lipidomics -- New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods -- Biological Membranes and Transport -- The Composition and Architecture of Membranes -- Membrane Dynamics -- Solute Transport across Membranes -- Methods: Atomic Force Microscopy to Visualize Membrane Proteins -- Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes -- Medicine: A Defective Ion Channel in Cystic Fibrosis -- Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry -- Expanded and updated section on lipid rafts and caveolae includes new material on membrane curvature and the proteins that influence it, and introduces amphitropic proteins and annular lipids -- New information on the structural basis for voltage gating in a K+ channel
520	2		_aIn the Fifth Edition, authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles through a variety of new learning tools--from new in-text worked examples and data analysis problems to the breakthrough eBook, which seamlessly integrates the complete text and its media components.
650	1	3	_aBioquímica _912849 _2atg
650	1	3	_aBiochemistry _9150448 _2atg
700	1		_aCox, Michael M. _928752 _eautor
901			_a574.192 N45 2008
902			_aA
905			_a5232272008 -usaimn8222223322eng16
942			_cLIBRO _2ddc
999			_c177373 _d177373